Flames and heavy smoke were reported about 3:10 a.m. in the 5200 block of S. Mason Avenue.
Smoke alarms alerted three people inside the home, and they were able to safely escape the blaze. Two residents were evaluated at the scene but were not taken to the hospital.
Crews were able to extinguish the fire, which spread through the interior and the back of the roof area.
Damages are estimated at $200,000.