After three years of effort, the city’s Landmarks Preservation Commission has given final approval to the design for a hotel in the Brewery District.

One of the owners, Faruq Ramzanalli of Seattle’s Hotel Concepts Inc., said after the decision Wednesday night that the company already is working to get permits and will start construction as soon as that is done, hopefully by the end of the year.

“We intend to go full speed ahead,” Ramzanalli said. The three-year process “has been challenging, but looking back, it’s been a good thing.”

Ramzanalli said Wednesday that he’s confident that the company’s financial backers will come through by the time Hotel Concepts is ready to break ground. “We think that by the time (the city permits) are ready, we’ll be ready,” he said.

Another owner, Han Kim, said in an interview last month that financing for the $20 million Holiday Inn Express was secured and that construction, once begun, would take about 15 months.

The hotel will be about 88,000 square feet and have about 160 rooms that go for about $100 a night, Kim said.

The hotel will occupy an existing parking lot and the site of an old, featureless warehouse at the intersection of 21st and C streets.